Nanoparticle formulations for delivering multiple therapeutic agents

摘要

A formulation for treating a patient with hepatocellular carcinoma is disclosed. The formulation comprises therapeutic agents in the form of nanoparticles containing one or more proteins or polysaccharides. The therapeutic agent is conjugated to an active targeting agent causing the formulation to preferentially segregate to the hepatocellular carcinoma tissue to release the therapeutic agents. Methods of treating hepatocellular carcinoma using the formulations are also disclosed.

主权项

1. A method of treating a patient for hepatocellular carcinoma with a formulation comprising therapeutic agents comprising:
a. forming a first solution of doxorubicin comprising one or more proteins or polymers; b. conjugating sorafenib with an active targeting ligand with one or more proteins to form a second solution; c. producing a formulation comprising nanoparticles using the first and the second solutions; and d. administering the nanoparticle formulation to a patient such that the targeting ligand causes the formulation to preferentially segregate to the hepatocellular carcinoma tissue to release the therapeutic agents; wherein the nanoparticles comprise polyvinyl alcohol forming a core and human serum albumin forming a shell; wherein the doxorubicin and the sorafenib are loaded onto the same nanoparticle such that doxorubicin is loaded onto the core and sorafenib is loaded onto the shell; wherein the ligand for targeting comprises transferrin; and wherein the formulation is administered by intraarterial delivery.