MUC-1 cytoplasmic domain peptides as inhibitors of cancer

摘要

Peptides from the Mucin 1 (MUC1) cytoplasmic domain and methods of use therefor are described. These peptides can inhibit MUC1 oligomerization, thereby preventing tumor cell growth, inducing tumor cell apoptosis and necrosis of tumor tissue in vivo.

主权项

1. A pharmaceutical composition comprising (a) a peptide of no more than 20 consecutive residues and comprising:
(i) the sequence CQCRRKN (SEQ ID NO: 53); and (ii) poly-R covering the amino-terminal cysteine of said peptide, and (b) a pharmaceutically acceptable carrier, buffer or diluent.