| 主权项 |
1. A compound of Formula (I):or an enantiomer, a mixture of enantiomers, or a mixture of two or more diastereomers thereof, or a pharmaceutically acceptable form thereof, wherein
Wb1 and Wb2 are each independently CR6, S, O, N or NR14, wherein at least one of Wb1 and Wb2 is CR6, N or NR14; Wb5 is CR8, CHR8, or N; p is 1; B is hydrogen, alkenyl, alkynyl, amino, heteroalkyl, cycloalkyl, heterocyclyl, aryl or heteroaryl, each of which is substituted with 0-4 R2; each R2 is independently alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxy, amido, amino, acyl, acyloxy, alkoxycarbonyl, sulfonamido, halo, cyano, hydroxyl, nitro, phosphate, urea or carbonate; X is absent or is (CH(R9))z—; Y is absent, —O—, —S—, —S(═O)—, —S(═O)2—, —N(R9)—, —C(═O)—(CHR9)z—, —C(═O)—, —N(R9)—C(═O)NH—, or —N(R9)C(R9)2—; each z is independently an integer of 1, 2, 3, or 4; R3 is a 6-membered heteroaryl or 6-membered heterocyclyl; wherein each of the above substituents is substituted with 0, 1, 2, or 3 R13; each R6 is independently hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, fluoroalkyl, heteroalkyl, alkoxy, amido, amino, acyl, acyloxy, sulfinyl, sulfonyl, sulfoxide, sulfone, sulfonamido, halo, cyano, heteroaryl, aryl, hydroxyl, or nitro; R8 is hydrogen, alkyl, alkenyl, alkynyl, cycloalkyl, heteroalkyl, alkoxy, amino, acyl, acyloxy, sulfonamido, halo, cyano, hydroxyl, or nitro; each R9 is independently hydrogen, alkyl, cycloalkyl, heterocyclyl or heteroalkyl; Wd isA is N or CR19;
R10, R11, R12, R13, and R19 are independently hydrogen, alkyl, heteroalkyl, alkenyl, alkynyl, cycloalkyl, heterocyclyl, aryl, arylalkyl, heteroaryl, heteroarylalkyl, alkoxy, heterocyclyloxy, amido, amino, acyl, acyloxy, alkoxycarbonyl, sulfonamido, halo, haloalkyl, cyano, hydroxyl, nitro, phosphate, urea, carbonate, oxo, or NR′R″ wherein R′ and R″ are taken together with nitrogen to form a cyclic moiety; and each R14 is independently hydrogen, alkyl, cycloalkyl, heterocyclyl or heteroalkyl. |
