发明名称 |
Pyridone derivatives and uses thereof in the treatment of tuberculosis |
摘要 |
A compound of Formula (I) is provided that has been shown to be useful for treating a disease, disorder or syndrome that is mediated by the inhibition of mycolic acid biosynthesis through inhibition of M. tuberculosis Enoyl Acyl Carrier Protein Reductase enzyme (InhA):;
wherein R1, R2, R3, R4 and R5 are as defined herein. |
申请公布号 |
US9546138(B2) |
申请公布日期 |
2017.01.17 |
申请号 |
US201314648217 |
申请日期 |
2013.12.12 |
申请人 |
Novartis AG |
发明人 |
Kondreddi Ravinder Reddy;Ma Ngai Ling;Peukert Stefan;Rao Srinivasa P S;Ujjini Manjunatha |
分类号 |
C07D213/69;C07F9/58;C07D401/06;C07D405/06;C07D213/64;A61K31/4412;A61K31/4433;A61K31/4439;A61K31/444;A61K31/675;A61K45/06;C07D401/04 |
主分类号 |
C07D213/69 |
代理机构 |
Genomics Institute of the Novartis Research Foundation |
代理人 |
Smith Chihang Amy;Genomics Institute of the Novartis Research Foundation |
主权项 |
1. A compound of Formula (I) wherein
R1 is H, methyl or ethyl;R2 is phenyl, wherein said phenyl is optionally substituted with one or more substituents independently selected from fluoro or chloro; provided that when said substituent is chloro, said chloro is on the meta or ortho position of said phenyl and the number of chloro substituent is not more than one;R3 is a structural formula selected from the group consisting of where R100 and R200 are each independently selected from the group consisting of H, (C1-C6)alkyl, and cycloalkyl;
R4 is H or —C(═O)NH2;R5 is selected from the group consisting of (C1-C6)alkyl, cycloalkyl, and phenyl, optionally substituted with one or more independent R300 substituents; andR300 is selected from the group consisting of H, (C1-C6)alkyl, cycloalkyl, hydroxy, amino and F; or a pharmaceutically acceptable salt thereof. |
地址 |
Basel CH |