Triazolo(4,5-D)pyrimidine compounds

摘要

Triazolo[4,5-d]pyrimidine compounds, their use as medicaments, compositions containing them and processes for their preparation. The compounds of the invention have the formula (I) as follows:;
wherein R, X and R1 through R3 are as defined in the specification.

主权项

1. A compound of formula (I)wherein:
R1 is C3-5 alkyl optionally substituted by one or more halogen atoms; R2 is a phenyl group, optionally substituted by one or more fluorine atoms; R3 and R4 are both hydroxy; R is XOH, where X is CH2, OCH2CH2 or a bond;or a pharmaceutically acceptable salt or solvate thereof, or a solvate of such a salt provided that:
when X is CH2 or a bond, R1 is not propyl; when X is CH2 and R1 is CH2CH2CF3, butyl or pentyl, the phenyl group at R2 must be substituted by fluorine; when X is OCH2CH2 and R1 is propyl, the phenyl group at R2 must be substituted by fluorine.