| 发明名称 | BAFF, inhibitors thereof and their use in the modulation of B-cell response and treatment of autoimmune disorders | ||
| 摘要 | The invention provides methods for treating or preventing disorders associated with expression of BAFF comprising BAFF and fragments thereof, antibodies, agonists and antagonists. | ||
| 申请公布号 | US9545086(B2) | 申请公布日期 | 2017.01.17 |
| 申请号 | US200812061398 | 申请日期 | 2008.04.02 |
| 申请人 | Biogen MA Inc. | 发明人 | MacKay Fabienne;Kalled Susan |
| 分类号 | A61K38/00;A01K67/027;C07K14/705;C07K16/28;C12N15/85;A61K39/00 | 主分类号 | A61K38/00 |
| 代理机构 | Finnegan, Henderson, Farabow, Garrett & Dunner, LLP | 代理人 | Finnegan, Henderson, Farabow, Garrett & Dunner, LLP |
| 主权项 | 1. A method of treating a mammal, the method comprising administering to a mammal having Sjögren's syndrome a composition comprising a BAFF blocking agent selected from the group consisting of: (a) a soluble BAFF receptor selected from a BAFF-R:Fc fusion, a BCMA:Fc fusion, and a TACI:Fc fusion; and (b) an antibody against a BAFF receptor selected from BAFF-R, BCMA, and TACI,thereby reducing immunoglobulin production or B cell growth in the mammal. | ||
| 地址 | Cambridge MA US | ||