Method of correcting for oxygen effect on test sensors

摘要

An electrochemical test sensor is adapted to measure glucose and correct for the oxygen effect in a fluid sample. The test sensor comprises a base, first and second working electrodes, and a counter electrode. The first working electrode includes glucose oxidase, a mediator and peroxidase. The second working electrode includes glucose oxidase and the mediator. The first working electrode, the second working electrode and the counter electrode are located on the base. In other embodiments, an electrochemical test sensor is adapted to measure cholesterol, lactate, pyruvate or xanthine and correct for the oxygen effect in a fluid sample.

主权项

1. A method for correcting the oxygen effect in determining the concentration of glucose in a fluid using an electrochemical test sensor, the method comprising the acts of:
providing a test sensor, the test sensor comprising a base, first and second working electrodes, and a counter electrode, the first working electrode including glucose oxidase, an oxidized form of a mediator and peroxidase, the second working electrode including glucose oxidase and the oxidized form of the mediator, the first working electrode, the second working electrode and the counter electrode being adjacent to the base; contacting the test sensor to a meter to form an electrical connection; placing the fluid on the test sensor; measuring a first current from the first working electrode from a reduced form of the mediator; measuring a second current from the second working electrode from the reduced form of the mediator; and determining the concentration of glucose and correcting for the oxygen effect, the oxygen effect being determined by subtracting the first current measurement from the second current measurement.