Method of stamping surface-enhance Raman spectroscopy for label-free, multiplexed, molecular sensing and imaging

摘要

The present disclosure relates the use of a stamping surface enhanced Raman scattering (S-SERS) technique with nanoporous gold disk (NPGD) plasmonic substrates to produce a label-free, multiplexed molecular sensing and imaging technique. A NPGD SERS substrate is stamped onto a surface containing one or more target molecules, followed by SERS measurement of the target molecules located between the surface and SERS substrate. The target molecules may be deposited on the surface, which may be a carrier substrate such as polydimethylsiloxane (PDMS).

主权项

1. A method of molecular sensing and imaging using stamping surface-enhanced Raman spectroscopy (S-SERS), the method comprising:
(a) depositing a surface-enhanced Raman spectroscopy (SERS) substrate on top of a surface comprising at least one target molecule; (b) stamping the SERS substrate onto the surface to produce a stamped SERS surface; and (c) taking SERS measurements directly from the at least one target molecule, wherein the at least one target molecule is positioned between the stamped SERS substrate and the surface, and wherein the SERS measurements provide sensing and imaging information about the target molecule.