发明名称 |
FREMGANGSMÅDER OG SAMMENSÆTNINGER TIL INFUSION AF UDVALGTE POPULATIONER AF ALLOGENE LYMFOCYTTER VED MIDLERTIDIG TRANSPLANTATION TIL BEHANDLING AF CANCER |
摘要 |
The invention provides methods and compositions for administration of allogeneic lymphocytes as an an exogenous source of CD4+ T cell help for endogenous, tumor-reactive CD8+ T cells. Depletion of CD8+ T cells from the donor lymphocyte infusion reduces the risk of sustained engraftment and graft-versus-host disease. Removal of regulatory T cells from the infused population may augment the ability of non-regulatory T cells to provide help for endogenous effectors of anti-tumor immunity. Allogeneic T cell therapy is typically given in the context of allogeneic stem cell transplantation, in which the patient receives highly immunosuppressive conditioning followed by an infusion of a stem cell graft containing unselected populations of mature T cells. In the treatment described here, the graft is engineered to minimize the possibility of sustained donor cell engraftment, and the anti-tumor effector T cells derive from the host. |
申请公布号 |
DK2846816(T3) |
申请公布日期 |
2017.01.16 |
申请号 |
DK20130788469T |
申请日期 |
2013.03.15 |
申请人 |
The Johns Hopkins University |
发明人 |
FUCHS, Ephraim, Joseph;SYMONS, Heather, Jill;SWINNEN, Lode |
分类号 |
A61K38/00;A61P7/00;A61P35/00;C12N5/078 |
主分类号 |
A61K38/00 |
代理机构 |
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代理人 |
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地址 |
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