发明名称 |
Sammensætninger og fremgangsmåder til levering af nitrogenoxid |
摘要 |
H-NOX proteins are mutated to exhibit improved or optimal kinetic and thermodynamic properties for blood gas O 2 delivery. The engineered H-NOX proteins comprise mutations that impart altered O 2 or NO ligand-binding relative to the corresponding wild-type H-NOX domain, and are operative as physiologically compatible mammalian blood O 2 gas carriers. The invention also provides pharmaceutical compositions, kits, and methods that use wild-type or mutant H-NOX proteins for the treatment of any condition for which delivery of O 2 is beneficial. |
申请公布号 |
DK2463294(T3) |
申请公布日期 |
2017.01.16 |
申请号 |
DK20110189807T |
申请日期 |
2007.05.21 |
申请人 |
The Regents of The University of California |
发明人 |
Cary, Stephen P. L.;Boon, Elizabeth M.;Marletta, Michael A.;Winger, Jonathan A. |
分类号 |
C07K14/00 |
主分类号 |
C07K14/00 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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