3,5,3'-TRIIODOTHYRONINE SULFATE AS THYROMIMETIC AGENT AND PHARMACEUTICAL FORMULATIONS THEREOF

摘要

The invention regards the use of triiodothyronine sulfate, commonly named T3S, as a medicament having thyromimetic activity for the treatment of pathologies due to organic deficiency of triiodothyronine (T3), as such or in association with thyroxine (T4), and pharmaceutical formulations for oral administration thereof.

主权项

1. A daily dosage thyroid hormone composition comprising T3S as the active principle, in a quantity ranging from 1 to 1000 μg;
at least one diluent selected from the group consisting of: microcrystalline cellulose, calcium carbonate, magnesium carbonate, and mixtures thereof; at least one glidant selected from the group consisting of: glycerol dibenhate and talc; at least one lubricant selected from the group consisting of: magnesium stearate, zinc stearate, and colloidal silica; and at least one disintegrant selected from the group consisting of: croscarmellose or salts thereof and crosovidone or salts thereof.