MULTI-POLYMER COMPOSITIONS FOR TRANSDERMAL DRUG DELIVERY

摘要

Multi-polymer compositions for the transdermal delivery of drugs, such as amine-functional drugs, in a flexible, finite form are described. The compositions comprise a polymer matrix that includes a drug or a pharmaceutically acceptable salt thereof and a polymer matrix comprising acrylic polymer(s), polyisobutylene polymer(s) and styrene-isoprene-styrene block copolymer(s). Methods of manufacturing and methods of using the compositions also are described.

主权项

1. A multi-polymer composition for the transdermal delivery of an amine-functional drug in the form of a flexible finite system for topical application, comprising a polymer matrix comprising (i) a therapeutically effective amount of an amine-functional drug; (ii) an acrylic polymer; (iii) a polyisobutylene polymer, and (iv) a styrene-isoprene-styrene block copolymer.