发明名称 |
MOLECULAR SENSORS |
摘要 |
The invention relates to a sensor molecule for detecting a target molecule comprising: (a) a rod-like molecule L and a rod-like molecule R connected to each other by a joint molecule C to form a hinge; (b) a target binding molecule A bonded to the end of rod- like molecule L opposite to the joint molecule C; (c) a binding molecule A' bonded to the end of rod-like molecule R opposite the joint molecule C; wherein the target binding molecule A is arranged to bind to the target molecule to be detected, and binding molecule A' is arranged to bind to: i) the same target molecule as target binding molecule A; or ii) a complex of the target binding molecule A and the target; and wherein the hinge is biased into an open position, such that target binding molecule Band binding molecule A' are biased apart by the hinge. The invention further relates to nucleic acid encoding such sensors, host cells comprising such sensor, and uses and methods of such sensors. |
申请公布号 |
WO2016139643(A9) |
申请公布日期 |
2017.01.12 |
申请号 |
WO2016IB51249 |
申请日期 |
2016.03.04 |
申请人 |
UNIVERSITY COLLEGE DUBLIN, NATIONAL UNIVERSITY OF IRELAND, DUBLIN |
发明人 |
MACKERNAN, Donal;SANYAL, Shourjya |
分类号 |
G01N33/542;A61K39/00;C12N15/62 |
主分类号 |
G01N33/542 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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