METHODS AND COMPOSITIONS FOR TREATING AND PREVENTING COGNITIVE DYSFUNCTION

摘要

The disclosure relates to methods and compositions for preventing or treating cognitive dysfunction. The methods comprise administering an effective amount of an aromatic-cationic peptide to subjects in need thereof. Specifically, the aromatic-cationic peptide has the formula D-Arg-2′,6′-Dmt-Lys-Phe-NH2, and the cognitive dysfunction is associated with a reduced cerebral metabolic rate of oxygen (CMRO).

主权项

1. A method for treating or preventing cognitive dysfunction associated with decreased cerebral metabolic rate of oxygen (CMRO) in a mammalian subject in need thereof, comprising administering to the subject a therapeutically effective amount of a peptide represented by the formula D-Arg-2′,6′-Dmt-Lys-Phe-NH2 or a pharmaceutically acceptable salt thereof.