发明名称 |
NOVEL LEDIPASVIR CRYSTAL FORM AND PREPARATION METHOD THEREOF |
摘要 |
The present invention relates to a novel Ledipasvir (LDV) crystal form and a preparation method thereof. Specifically, disclosed is an LDV solvate. The solvate is a solvate formed by LDV and a solvent A and/or a solvent B, wherein the solvent A is acetonitrile or acetone; and the solvent B is methyl tertiary butyl ether (MTBE). Also disclosed are a preparation method and an application of the solvate. The solvate has a high purity, a good crystallization property, and better optical stability. The preparation method is simple and the process is stable. The solvate can significantly improve quality control and industrial applications of LDV-containing drugs. |
申请公布号 |
WO2017005104(A1) |
申请公布日期 |
2017.01.12 |
申请号 |
WO2016CN87090 |
申请日期 |
2016.06.24 |
申请人 |
SHANGHAI FOREFRONT PHARMCEUTICAL CO., LTD |
发明人 |
LI, Wei;REN, Yi;HUANG, Chengjun;ZHU, Yanyan;FU, Shaojun;FU, Gang;WEI, Zhewen |
分类号 |
C07D403/14;A61K31/4184;A61P31/14 |
主分类号 |
C07D403/14 |
代理机构 |
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代理人 |
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地址 |
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