发明名称 |
METHOD TO OBTAIN UNBIASED IDENTIFICATION OF INTERACTION OF TEST COMPOUNDS WITH THE PROTEOME |
摘要 |
The invention provides an unbiased method to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells by applying the unbiased determination technique of SWATH-MS or the biased technique of SRM-MS to a thermal shift assay to evaluate drug target interactions. In addition, the results created by SWATH-MS can be analyzed by SRM-MS in a biased manner to assess the binding of a test compound to a multiplicity of proteins in the same sample, including samples from living cells. |
申请公布号 |
WO2017007849(A1) |
申请公布日期 |
2017.01.12 |
申请号 |
WO2016US41188 |
申请日期 |
2016.07.06 |
申请人 |
INSTITUTE FOR SYSTEMS BIOLOGY |
发明人 |
MORITZ, Robert, L.;BADER, Samuel;KUSEBAUCH, Ulrike |
分类号 |
C07K1/32;G01N1/44;G01N33/53;G01N33/68 |
主分类号 |
C07K1/32 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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