CRYSTALLINE FORM OF OXAZOLIDINONE ANTIBIOTICS AND PREPARATION METHOD, COMPOSITION AND USE THEREOF

摘要

The present invention relates to a novel crystal form of oxazolidinone antibiotics. The new crystalline form has advantages in the aspects of solubility, hygroscopicity, crystallinity and stability. The present invention also relates to a method for preparing the new crystalline form, a pharmaceutical composition thereof and the use thereof in the preparation of drugs for treating and/or preventing diseases caused by microbial infection.

主权项

1. Form II of (R)-3-(4-(2-(2-methyltetrazol-5-yl) pyridine-5-yl)-3-fluorophenyl)-5-hydroxymethyl oxazolidin-2-one dihydrogen phosphate represented by the following structural formula:measured with Cu-Kα radiation, the X-ray powder diffraction pattern of the Form II, expressed as 2θ angles, has the following characteristic peaks: 10.5±0.2°, 15.7±0.2°, 16.5±0.2°, 17.3±0.2°, 21.0±0.2° and 26.3±0.2°.