PHOSPHOROUS-AND SULFUR-SUBSTITUTED BENZODIAZEPINE DERIVATIVES

摘要

The invention relates to bromodomain-protein-inhibiting, in particular BET-protein-inhibiting, and preferably BRD4-inhibiting phosphorous- and sulfur-substituted benzodiazepine derivatives of the general formula (I), in which R1, R2, R3, R4, and R5 have the meanings as specified in the description, to pharmaceutical agents containing the compounds according to the invention, and to the prophylactic and therapeutic use thereof in hyper-proliferative diseases, in particular in tumor diseases. The invention further relates to the use of BET protein inhibitors in benign hyperplasias, atherosclerotic diseases, sepsis, autoimmune diseases, vascular disorders, viral infections, HIV-associated kidney diseases, neurodegenerative diseases, inflammatory diseases, atherosclerotic diseases, cardiac insufficiency, muscular dystrophies such as, for example, facioscapulohumeral muscular dystrophy, and in male fertility control.