MICROORGANISM HAVING REGULATED EXPRESSION OF (R)-SPECIFIC ENOYL-COA HYDRATASE GENE AND METHOD FOR PRODUCING POLYHYDROXYALKANOATE COPOLYMER USING SAME

摘要

This invention relates to a microorganism that produces a polyhydroxyalkanoate (PHA) copolymer with a regulated monomer composition ratio and comprises a (R)-specific enoyl-CoA hydratase gene in the genome DNA, wherein a nucleotide sequence upstream of the (R)-specific enoyl-CoA hydratase gene comprises a modification consisting of a substitution(s), a deletion(s), an insertion(s), and/or an addition(s) of one or a plurality of nucleotides so that the expression of the (R)-specific enoyl-CoA hydratase gene is regulated, and to a method for producing a PHA copolymer using the microorganism.

主权项

1. A microorganism comprising a (R)-specific enoyl-CoA hydratase gene in genome DNA, wherein a nucleotide sequence upstream of the (R)-specific enoyl-CoA hydratase gene comprises a modification that includes a substitution, a deletion, an insertion, and/or an addition of at least one nucleotide so that expression of the (R)-specific enoyl-CoA hydratase gene is regulated.