BENZENDE SULFONAMIDE DERIVATIVES AS HIV INTEGRASE INHIBITORS

摘要

Methods for treating retroviral infection or inhibiting HIV integrase in target cells or in a patient involve administering to target cells or to a patient in need of treatment an effective amount of at least one having a disulfonamide scaffold which is represented by the formula:;;wherein, independent of each other,
each X independently represents hydrocarbyl, halogeno, amino, substituted amino, or alkoxy, wherein substituted amino is represented by —NR3,R4 wherein R3 and R4, are not both hydrogen and independently represent alkyl or alkenyl,n is an integer of 0, 1, 2, or 3,each Y independently represents hydrocarbyl, halogeno, amino, substituted amino or alkoxy,wherein substituted amino is represented by —NR3,R4 wherein R3 and R4, are not both hydrogen and independently represent alkyl or alkenyl,m is an integer of 0, 1, 2, or 3, andR represents di-valent hydrocarbyl, substituted or unsubstituted.

主权项

1. A method for inhibiting HIV integrase in target cells or in a patient comprises administering to said target cells or to a patient in need of treatment an effective amount of at least one anti-viral compound, wherein the anti-viral compound comprises a compound having disulfonamide scaffold represented by the following general formula (1):wherein, independent of each other,
each X independently represents hydrocarbyl, halogeno, amino, substituted amino, or alkoxy, wherein substituted amino is represented by —NR3,R4 wherein R3 and R4, are not both hydrogen and independently represent alkyl or alkenyl, n is an integer of 0, 1, 2, 3 or 4, each Y independently represents hydrocarbyl, halogeno, amino, substituted amino or alkoxy, wherein substituted amino is represented by —NR3,R4 wherein R3 and R4, are not both hydrogen and independently represent alkyl or alkenyl, m is an integer of 0, 1, 2, 3 or 4, and R represents di-valent hydrocarbyl, substituted or unsubstituted.