MATERIALS, METHODS AND DEVICES FOR ALTERING CELL REACTIVITY

摘要

Methods, compositions, and devices to limit, modulate, insulate, and/or otherwise alter the effects of exogenous physical stimuli on cells are described herein. The cells may be removed from the body, preferably isolated, and treated ex vivo with the composition to limit the effects of physical stimuli on the cells and then returned to the patient. Alternatively, the cells may be treated in vivo. The compositions can be administered a variety of manners, such as systemically, locally or regionally.

主权项

1. A method of limiting cell and cell fragment reactivity to exogenous physical forces comprising administering to cells subjected to exogenous physical forces, a composition selected from the group consisting of a composition comprising (i) one or more agents in an effective amount to modulate membrane function and/or stability; (ii) one or more agents in an effective amount to alter sub-membrane assemblies involved in mechano-transduction; (iii) one or more agents in an effective amount to modulate intracellular microfilament/microtubule function; (iv) one or more agents in an effective amount to modulate intracellular fluid content and tonicity; (v) one or more polymers; and (vi) combinations thereof.