REDUCING HORIZONTAL GENE TRANSFER OF FUNCTIONAL PROTEINS

摘要

Disclosed are methods and compositions for reducing horizontal gene transfer of functional proteins. In some embodiments, the risk of horizontal gene transfer of a functional protein is reduced by separately encoding domains of a protein on at least two spatially distinct nucleic acid sequences, where each individual domain alone is non¬ functional, but co-expression of the encoded domains results in their association to form a functional protein.