发明名称 |
アルツハイマー病の診断のための繊維芽細胞成長パターン |
摘要 |
Methods of diagnosing Alzheimer's disease are provided. At least five methods of diagnostic measurements are presented: Method 1: Integrated score; Method 2: Average aggregate area per number of aggregates; Method 3: Cell migration analysis; Method 4: Fractal analysis; Method 5: Lacunarity Analysis. In certain embodiments, a sample of a subject's skin provides a network of fibroblasts that is imaged and a fractal dimension of the image is calculated. The fractal dimension can be compared to an aged-matched control (non-Alzheimer's) database to determine if the subject has Alzheimer's disease. The network of fibroblasts may be cultured in a matrix, for example in a protein mixture. |
申请公布号 |
JP6058395(B2) |
申请公布日期 |
2017.01.11 |
申请号 |
JP20120532380 |
申请日期 |
2010.10.02 |
申请人 |
ブランシェット・ロックフェラー・ニューロサイエンスィズ・インスティテュート |
发明人 |
チリラ、フロリン・バレンティン;カーン、タパン・クマー;アルコン、ダニエル・エル. |
分类号 |
G01N33/48;C12Q1/06;G01N33/483 |
主分类号 |
G01N33/48 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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