发明名称 |
CRYSTAL FORM OF DABIGATRAN ETEXILATE MESYLATE AND PREPARATION METHOD AND USE THEREOF |
摘要 |
The present invention relates to novel crystal forms M and N of dabigatran etexilate mesylate and preparation method and uses thereof, wherein the X-Ray powder diffractogram of the crystal form M has characteristic peaks at the following 2¸ diffraction angles: 5.7±0.2°, 6.2±0.2°, 11.2±0.2°, 12.4±0.2°, 18.2±0.2°, 21.4±0.2°, 21.8±0.2° and 23.6±0.2°; and the X-Ray powder diffractogram of the crystal form N has characteristic peaks at the following 2¸ diffraction angles: 6.0±0.2°, 11.8±0.2°, 18.2±0.2°, 21.6±0.2°, 24.4±0.2°, 27.7±0.2° and 29.7±0.2°. The crystal forms of the present invention have excellent properties in the aspects of leaching time, biological release, chemical stability and processing adaptability. |
申请公布号 |
EP3115360(A1) |
申请公布日期 |
2017.01.11 |
申请号 |
EP20150759282 |
申请日期 |
2015.03.04 |
申请人 |
Zhejiang Hisun Pharmaceutical Co. Ltd. |
发明人 |
ZHANG, Liang;LIU, Chuan;XU, Jinyi;ZHANG, Zhaozhao;CHEN, Zhi;CHAI, Jian;YANG, Zhiqing;LUO, Hairong;ZHANG, Xiangyang |
分类号 |
C07D401/12;A61K31/4439;A61P7/02;C07C303/44;C07C309/04 |
主分类号 |
C07D401/12 |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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