摘要 |
Recombinant collagenases with a stable specific activity and enzyme agents for cell and tissue dissociation such a recombinant are provided. The recombinant collagenase is derived from Grimontia hollisae -derived collagenase is characterized by having, from the N terminus to the C terminus, a collagenase catalytic domain, a linker region sequence, and a prepeptidase C terminal domain, which Grimontia hollisae -derived recombinant collagenase does not comprise at least the prepeptidase C terminal domain. The obtained recombinant collagenase has a high and stable specific activity. |
申请人 |
NIPPI, INCORPORATED;THE UNIVERSITY OF TOKYO |
发明人 |
TERAMURA, Naoko;IIJIMA, Katsumasa;HAYASHIDA, Osamu;TANAKA, Keisuke;HATTORI, Shunji;OKITSU, Teru;TAKEUCHI, Shoji |