| 摘要 |
The invention provides compositions and methods for reducing healing wounds and reducing scars and blemishes. The compositions and methods of the invention include at least one EP4 agonist set forth herein. Wounds and or scars that can be treated by the compositions and methods of the invention can arise from events such as surgery, trauma, disease, mechanical injury, burn, radiation, poisoning, and the like. |
| 主权项 |
1. A compound of Formula I:wherein:
Y is O; Z is CH2; Q is aryl or heteroaryl, wherein said aryl and heteroaryl groups are optionally substituted with one or more R6; U is aryl or heteroaryl, wherein said aryl and heteroaryl groups are optionally substituted with one or more R7; V is aryl or heteroaryl; wherein said aryl and heteroaryl groups are optionally substituted with one or more R8; R1 is —ORa, wherein Ra is H; R2 is H; each R3, R4 and R5 is H; each R6 is independently —CO2Re, —CH2ORe, —CONReRf, or tetrazol-5-yl; wherein each Re is independently H, C1-C6 alkyl, haloalkyl, hydroxyalkyl, or aryl, and each Rf is independently H, C1-C6 alkyl, C(O)Rg, or SO2Rg, wherein Rg is C1-C6 alkyl, CF3, aryl, or heteroaryl; each R7 is independently H, C1-C6 alkyl, haloalkyl, halo, hydroxyl, nitro, cyano, or amino; each R8 is independently H, C1-C6 alkyl, haloalkyl, hydroxyalkyl, hydroxyl, halo, aryl, or heteroaryl; and m is 1; wherein the dashed line represents the presence of a bond, and wherein the resulting olefin geometry is trans; each aryl is C6 aryl; and each heteroaryl comprises 5 or 6;or a pharmaceutically acceptable salt thereof. |
