| 发明名称 | Methods for predicting pregnancy outcome in a subject by hCG assay | ||
| 摘要 | The present invention provides a method of predicting pregnancy outcome in a subject by determining the amount of an early pregnancy associated molecular isoform of hCG in a sample. The present invention further provides a method for determining the amount of early pregnancy associated molecular isoforms of human chorionic gonadotropin (hCG) in a sample. The present invention also provides a diagnostic kit for determining the amount of early pregnancy associated hCG in a sample. The present invention additionally provides an antibody which specifically binds to an early pregnancy associated molecular isoform of human chorionic gonadotropin. Finally, the present invention provides methods for detecting trophoblast or non-trophoblast malignancy in a sample. | ||
| 申请公布号 | US9541563(B2) | 申请公布日期 | 2017.01.10 |
| 申请号 | US201414228720 | 申请日期 | 2014.03.28 |
| 申请人 | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK | 发明人 | O'Connor John F.;Kovalevskaya Galina I.;Birken Steven |
| 分类号 | G01N33/76;C07K14/59;C07K16/26;G01N33/574 | 主分类号 | G01N33/76 |
| 代理机构 | Cooper & Dunham LLP | 代理人 | White John P.;Cooper & Dunham LLP |
| 主权项 | 1. A diagnostic kit for determining amount of an early pregnancy associated molecular isoform of human chorionic gonadotropin (EPMI-hCG) in a sample comprising (a) a capturing antibody which specifically or preferentially binds to EPMI-hCG recognized by the antibody produced by the hybridoma deposited with the American Type Culture Collection under Designation No. HB-12467; and (b) reagents permitting the formation of a complex between the capturing antibody and EPMI-hCG in the sample, wherein the capturing antibody is B152. | ||
| 地址 | New York NY US | ||