Speckle contrast optical tomography

摘要

Speckle contrast optical tomography system provided with at least one point source and multiple detectors, means for providing different source positions, the point source having a coherence length of at least the source position-detector distance and means for arranging the source position-detector pairs over a sample to be inspected, the system being further provided with means for measuring the speckle contrast; the speckle contrast system of the invention thus capable of obtaining 3D images.

主权项

1. A speckle contrast optical tomography system comprising:
a plurality of point sources each adapted to generate light, each of the plurality of point sources located at a respective first location over a sample to be examined; a plurality of detectors located at respective second locations relative to the sample; and wherein the plurality of point sources and the plurality of detectors are arranged over a tissue volume of the sample in an arrangement that defines a plurality of source position-detector pairs adapted to examine the tissue volume; the speckle contrast optical tomography system further comprising:
a processing device adapted to:
determine a speckle contrast between each of the plurality of source position-detector pairs, after light transverses the tissue volume, both in the absence of flow and in the presence of flow, thereby generating speckle contrast data;correct the speckle contrast data for shot-noise error and intensity gradients; andconstruct a speckle contrast forward model by performing the following steps:
computing a field autocorrelation for the plurality of source positions and the plurality of detectors;computing the speckle contrast for the plurality of source positions and the plurality of detectors;computing a difference value defining a relationship between the speckle contrast corrected for shot noise and intensity gradients and a baseline speckle contrast measurement value; anddetermining a linear system of equations having a solution that provides a flow contrast, based at least in part on the difference value.