| 发明名称 | Innovative discovery of therapeutic, diagnostic, and antibody compositions related to protein fragments of Cysteinyl-tRNA synthetase | ||
| 摘要 | Provided are compositions comprising newly identified protein fragments of aminoacyl-tRNA synthetases, polynucleotides that encode them and complements thereof, related agents, and methods of use thereof in diagnostic, drug discovery, research, and therapeutic applications. | ||
| 申请公布号 | US9540629(B2) | 申请公布日期 | 2017.01.10 |
| 申请号 | US201514616015 | 申请日期 | 2015.02.06 |
| 申请人 | aTyr Pharma, Inc.;Pangu BioPharma Limited | 发明人 | Greene Leslie Ann;Chiang Kyle P.;Hong Fei;Vasserot Alain P.;Lo Wing-Sze;Watkins Jeffry D.;Quinn Cheryl L.;Mendlein John D. |
| 分类号 | C07C11/167;C12N15/52;C12N15/70;C12N9/00;C07K16/40;G01N33/573;A61K38/00 | 主分类号 | C07C11/167 |
| 代理机构 | Cooley LLP | 代理人 | Cooley LLP |
| 主权项 | 1. An isolated polynucleotide that encodes an aminoacyl-tRNA synthetase (AARS) polypeptide consisting of a sequence that is at least 95% identical over the entire length of SEQ ID NO: 12, 18, or 36 or a fragment thereof which is 90 or more contiguous amino acids of SEQ ID NO: 12, 18, or 36 wherein the polynucleotide is selected from (a) a cDNA polynucleotide and (b) a modified mRNA polynucleotide and wherein the encoded AARS polypeptide has an extracellular signaling activity. | ||
| 地址 | San Diego CA US | ||