| 发明名称 | Polynucleotide encoding antibody to human IL-3 receptor alpha chain | ||
| 摘要 | The present invention provides an antibody to human IL-3Rα chain, which does not inhibit IL-3 signaling and binds to B domain of the human IL-3Rα chain but does not bind to C domain of the human IL-3Rα chain; a composition for preventing or treating a blood tumor in which a cell expressing IL-3Rα is found in bone marrow or peripheral blood of a subject, which comprises the antibody to human IL-3Rα as an active ingredient; and a method for treating a blood tumor in which a cell expressing IL-3Rα is found in bone marrow or peripheral blood, which comprises administering, to a subject, a composition comprising the IL-3Rα antibody as an active ingredient. | ||
| 申请公布号 | US9540441(B2) | 申请公布日期 | 2017.01.10 |
| 申请号 | US201615182891 | 申请日期 | 2016.06.15 |
| 申请人 | KYOWA HAKKO KIRIN CO., LTD | 发明人 | Tawara Tomonori;Takayanagi Shinichiro;Inagaki Yoshimasa |
| 分类号 | C12N5/10;C12N15/12;C12N15/63;C07K16/28;G01N33/574 | 主分类号 | C12N5/10 |
| 代理机构 | Sughrue Mion, PLLC | 代理人 | Sughrue Mion, PLLC |
| 主权项 | 1. A polynucleotide encoding an antibody to a human IL-3Rα chain, wherein said antibody does not inhibit IL-3 signaling and binds to the B domain of the human IL-3Rα chain but does not bind to the C domain of the human IL-3Rα chain, and wherein said antibody binds to a region within positions 101-203 of SEQ ID NO: 2, but does not bind to any region within positions 204-308 of SEQ ID NO: 2. | ||
| 地址 | Tokyo JP | ||