发明名称 |
Crystals of dispiropyrrolidine derivatives |
摘要 |
Crystals of a dispiropyrrolidine compound or a salt thereof which inhibits the action of Mdm2 are provided. The present invention provides crystals of (3′R,4′S,5′R)-N-[(3R,6S)-6-carbamoyltetrahydro-2H-pyran-3-yl]-6″-chloro-4′-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2″-oxo-1″,2″-dihydrodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indole]-5′-carboxamide or a salt thereof which inhibits Mdm2 and has anti-tumor activity. The present invention also provides a medicament comprising the same. |
申请公布号 |
US9540386(B2) |
申请公布日期 |
2017.01.10 |
申请号 |
US201615144485 |
申请日期 |
2016.05.02 |
申请人 |
Daiichi Sankyo Company, Limited |
发明人 |
Yoshida Shoko;Sugimoto Yuuichi |
分类号 |
C07D487/10;A61K31/4439 |
主分类号 |
C07D487/10 |
代理机构 |
Dorsey & Whitney LLP |
代理人 |
Dorsey & Whitney LLP |
主权项 |
1. A crystal of (3′R,4′S,5′R)-N-[(3R,6S)-6-carbamoyltetrahydro-2H-pyran-3-yl]-6″-chloro-4′-(2-chloro-3-fluoropyridin-4-yl)-4,4-dimethyl-2″-oxo-1″,2″-dihydrodispiro[cyclohexane-1,2′-pyrrolidine-3′,3″-indole]-5′-carboxamide represented by the following formula (1):wherein:
the crystal is a benzenesulfonate salt; and the crystal has the X-ray diffraction pattern as shown in FIG. 8 as determined by X-ray powder diffraction obtained by copper Kα radiation (wavelength λ=1.54 angstroms). |
地址 |
Tokyo JP |