Imidazole-1-yl pyrimidine derivatives, or pharmacutically acceptable salt thereof, and pharmaceutic composition comprising the same as an active ingredient

摘要

The present invention relates to a novel imidazole-1-yl pyrimidine derivative, a pharmaceutically acceptable salt thereof, and a pharmaceutic composition comprising the same. Since the imidazole-1-yl pyrimidine derivative according to the present invention shows the inhibition activity selectively to BRAF, BRAF mutants, or CRAF, it can be used to a pharmaceutic composition for preventing or treating cancer.

主权项

1. An imidazole-1-yl pyrimidine derivative represented by the following Chemical Formula 1, or a pharmaceutically acceptable salt thereof: in Chemical Formula 1, Q1 is —CH2— or —CO—; Q2 is —CO— or —CONH—; R1 is a C6-C20 aryl, a C7-C20 alkylaryl, a C7-C20 arylalkyl, a C5-C20 heteroaryl, a C3-C20 cycloalkyl, or a C3-C20 heterocycloalkyl, wherein said R1 is substituted with a halogen, a halogenated alkyl, hydroxyl group, carbonyl group, cyano group, alkoxy group, or a C3-C20 heterocycloalkyl or not.