| 发明名称 | Compositions and methods for treating IgE-mediated disorders | ||
| 摘要 | The present invention relates to immunoglobulins that bind IgE and FcγRIIb with high affinity, said compositions being capable of inhibiting cells that express membrane-anchored IgE. Such compositions are useful for treating IgE-mediated disorders, including allergies and asthma. | ||
| 申请公布号 | US9540451(B2) | 申请公布日期 | 2017.01.10 |
| 申请号 | US201313860484 | 申请日期 | 2013.04.10 |
| 申请人 | Xencor, Inc. | 发明人 | Desjarlais John R.;Chu Seung Y.;Horton Holly M.;Bernett Matthew J. |
| 分类号 | C07K16/42;C07K16/46 | 主分类号 | C07K16/42 |
| 代理机构 | Morgan, Lewis & Bockius, LLP | 代理人 | Silva Robin M.;Nguyen Louis T.;Morgan, Lewis & Bockius, LLP |
| 主权项 | 1. An antibody comprising a variable region and variable Fc region as compared to a human IgG Fc region, wherein said variable region binds membrane anchored IgE, wherein the variable heavy chain of said variable region comprises SEQ ID NO: 17, wherein the variable light chain of said variable region comprises SEQ ID NO: 21, and wherein said Fc region is a variable Fc region comprising an amino acid substitution at position 267, wherein said substitution is 267E or 267D, and wherein said numbering is according to the EU index of Kabat. | ||
| 地址 | Monrovia CA US | ||