Cell bandage

摘要

The invention provides a method for delivering cells across the surface of a tissue, the method comprising distributing the cells on and/or within a sheet of biomaterial to form a cell bandage and applying the cell bandage to the surface, wherein, after application of the cell bandage to the surface of the tissue, the cells are released from the cell bandage. Further provided is a method for bonding two or more tissues, the method comprising providing a cell bandage in intimate contact with the surfaces to be joined, wherein the cell bandage comprises a sheet of biomaterial, said biomaterial having cells distributed on and/or within it. Also provided is a cell bandage for use in the methods of the invention.

主权项

1. A cell bandage comprising
a sheet of biomaterial, wherein said biomaterial has cells distributed on and within it, said sheet has cells at or on both surfaces, and the biomaterial is rough on both of said surfaces and has an open structure at both said surfaces, thereby promoting release of said cells from each surface of the bandage following surgical implantation and promoting migration of cells from each surface of the bandage following a surgical implantation, wherein said cell bandage is less than 1.0 mm thick, and is for applying cells in close apposition to the surface of a tissue, and said biomaterial is biodegradable in vivo.