Acid-substituted polyaniline-grafted hydrogel copolymer and use thereof

摘要

An (acid-substituted polyaniline)-grafted hydrogel copolymer is provided. The (acid-substituted polyaniline)-grafted hydrogel copolymer has a general formula as below:;
wherein A is a proton acid group, m and n are same or different integers greater than 0, x is an integer equal to or greater than 0, and y is an integer equal to or greater than 1, provided that x and y are the same or different at each occurrence, and at least an x is not 0. The (acid-substituted polyaniline)-grafted hydrogel copolymer is formed by the polymerization and substitution reaction between chitosan, polyaniline, and proton acid. The (acid-substituted polyaniline)-grafted hydrogel copolymer behaves as a pH-responsive hydrogel with photo-thermal properties and can be applied to photo-thermal therapy.

主权项

1. A method of treating a bacterial infection comprising sequentially performing following steps:
a) injecting a photo-thermal agent having the general formula shown as below at an infection site that is caused by bacteria, the photo-thermal agent is formed from a chitosan group, a polyaniline group, and a proton acid group by a polymerization process: wherein A is a proton acid group, m and n are same or different integers greater than 0, x is an integer equal to or greater than 0, and y is an integer equal to or greater than 1, provided that x and y are the same or different at each occurrence, and at least an x is not 0; wherein the proton acid group is selected from the group consisting of: 3-mercapto-1-propanesulfonic acid sodium salt (MPS-Na), 3-mercaropropinoic acid, and thioglycolic acid; and b) exposing the infection site to Near-Infrared light for generating a heat energy to kill the bacteria inside the infection site.