Lipid-containing PSA compositions, methods of isolation and methods of use thereof

摘要

The invention provides compositions comprising lipid-conjugated forms of capsular polysaccharide A (PSA) from B. fragilis (referred to herein as PSA-LT), methods of isolating such forms and of making such compositions and methods for their use.

主权项

1. A pharmaceutical composition comprising:
an isolated lipidated polysaccharide A (PSA) comprising a PSA polysaccharide covalently conjugated to a lipid, and a pharmaceutically-acceptable carrier or excipient, wherein the composition is suitable for administration to a human.