| 发明名称 | Formulation of liposomal vesicles in aqueous solutions with lachrymal film characteristics | ||
| 摘要 | The present invention involves the preparation of a pharmaceutical liposomal system in an aqueous solution which contains a substance or polymer with mucomimetic and/or mucoadhesive properties. Due to the components and characteristics of the formulation described in this present patent it can be used as a precorneal tear film substitute. This invention is included in the pharmacy and medicine areas. | ||
| 申请公布号 | US9539202(B2) | 申请公布日期 | 2017.01.10 |
| 申请号 | US200711796747 | 申请日期 | 2007.04.27 |
| 申请人 | UNIVERSIDAD COMPLUTENSE DE MADRID | 发明人 | Herrero Vanrell Rocio;Benitez Del Castillo Jose;Vico Ruiz Eva;Vicario De La Torre Marta;Molina Martinez Irene Teresa |
| 分类号 | A61K9/127;A61K31/00;A61K31/70;A61K31/728;A61K38/00;A61K9/00;A61K31/07;A61K31/20;A61K31/375;A61K31/56;A61K33/00;A61K38/17;A61K38/18;A61K38/30;A61K38/38;A61K38/40;A61K38/47;A61K38/57 | 主分类号 | A61K9/127 |
| 代理机构 | Ladas & Parry LLP | 代理人 | Ladas & Parry LLP |
| 主权项 | 1. An ophthalmic composition for use as a precorneal film substitute, comprising phosphatidylcholine liposomal vesicles obtained from soy lecithin containing α-tocopherol and cholesterol, wherein the liposomal vesicles, once formed, are dispersed in aqueous solution with trehalose and hyaluronic acid, and wherein the trehalose is present in the composition in an amount effective to render the ophthalmic composition isotonic or hypotonic in clinical use in a human eye. | ||
| 地址 | Madrid ES | ||