(−)-(2R,3S)-2-amino-3-hydroxy-3-pyridin-4-yl-1-pyrrolidin-1-yl-propan-1-one (L)-(+) tartrate salt, its method of production and use

摘要

The present invention is directed to (−)-(2R,3S)-2-amino-3-hydroxy-3-pyridin-4-yl-1-pyrrolidin-1-yl-propan-1-one (L)-(+) tartrate salt, a pharmaceutical composition comprising said salt, a process for making said salt, and the use of said salt in the treatment of pain.

主权项

1. A salt that is (−)-(2R,3S)-2-amino-3-hydroxy-3-pyridin-4-yl-1-pyrrolidin-1-yl-propan-1-one (L)-(+) tartrate salt in crystalline form and having an X-ray powder diffraction spectrum with peaks expressed in degrees (2θ) at approximately 7.61, 7.89, 12.97, 13.50, 15.13, 15.19, 15.38, 16.23, 16.71, 16.83, 17.05, 19.76, 20.14, 20.43, 20.76, 21.00, 22.77, 22.86, 23.07, 23.66, 24.58, 24.90, 25.11, 25.35, 25.63, 25.83, 26.33, 27.09, 28.08, 30.71, 31.02, 31.72, 33.00 and 34.15.