Nitric oxide-releasing diazeniumdiolated polyvinylpyrrolidone-based polymers, and compositions, medical devices, and uses thereof

摘要

Disclosed is a nitric oxide-releasing polyvinylpyrrolidone-based polymer derived from N-vinylpyrrolidone monomer and at least one nitric oxide releasing N2O2− group, in which the N2O2− group is attached to a 2 pyrrolidinone group or a group derived therefrom in the N-vinylpyrrolidone monomer, and the polymer is optionally in combination with a substrate. The NO-releasing polymer can be part of a medical device or pharmaceutical composition and is useful for treating a biological disorder, such as healing a wound, restenosis, and/or promoting angiogenesis.

主权项

1. A nitric oxide-releasing polyvinylpyrrolidone-based polymer comprising at least one monomer unit derived from N-vinylpyrrolidone and at least one monomer unit selected from the group consisting of formula (I) and formula (II) or a composite comprising the polymer in combination with a substrate, wherein R1 is —CH2CH2CR4R5C(O)OR6, R2, R3, R4, and R5 are the same or different and each is H or N2O2M, M is hydrogen ion or a pharmaceutically acceptable cation, and R6 is H, an unsubstituted or substituted C1-12 alkyl, an unsubstituted or substituted C2-8 alkenyl, an unsubstituted or substituted C3-C6 cycloalkyl, a substituted or unsubstituted aryl, or C1-12 trialkylsilyl, provided at least one of R2-5 is N2O2M in formula (I) and formula (II).