| 发明名称 | Human antibodies and antibody-drug conjugates against CD74 | ||
| 摘要 | Isolated human monoclonal antibodies which bind to human CD74 and related antibody-drug conjugates are disclosed. Pharmaceutical compositions comprising the antibodies or antibody-drug conjugates, and therapeutic and diagnostic methods for using the antibodies and/or antibody-drug conjugates, are also disclosed. | ||
| 申请公布号 | US9540433(B2) | 申请公布日期 | 2017.01.10 |
| 申请号 | US201213982959 | 申请日期 | 2012.02.01 |
| 申请人 | GENMAB A/S | 发明人 | Verploegen Sandra;Overdijk Marije;Dijkhuizen Riemke Van;Bleeker Willem Karel;Van Berkel Patrick;Parren Paul;Lisby Steen |
| 分类号 | A61K39/395;C07K16/28;C07K16/30;C07K16/42;C07K16/18;A61K47/48;A61K51/10;A61K31/7088;A61K35/17;A61K35/76;A61K38/16;A61K38/19;A61K45/06;A61K39/00 | 主分类号 | A61K39/395 |
| 代理机构 | Nelson Mullins Riley & Scarborough LLP | 代理人 | Nelson Mullins Riley & Scarborough LLP ;Remillard, Esq. Jane E.;Frank Christopher L. |
| 主权项 | 1. An antibody which binds to CD74 variants 1 and 2 and comprises a VL region comprising the CDR1, 2 and 3 sequences set forth in SEQ ID NO:24, SEQ ID NO:27, and SEQ ID NO:25, respectively, and a) a VH region comprising the CDR1, 2 and 3 sequences set forth in SEQ ID NO: 20, 21 and 22, respectively; b) a VH region comprising the CDR1, 2 and 3 sequences set forth in SEQ ID NOS:8, 9 and 10, respectively; c) a VH region comprising the CDR1, 2 and 3 sequences set forth in SEQ ID NO: 12, 13 and 14, respectively; or d) a VH region comprising the CDR1, 2 and 3 sequences set forth in SEQ ID NO: 16, 17 and 18, respectively. | ||
| 地址 | Copenhagen DK | ||