Modulating disease through genetic engineering of plants

摘要

In certain embodiments transgenic plants (e.g., transgenic tomatoes) are provided that comprise cells that express a peptide one or more domains of which comprise the amino acid sequence of an apolipoprotein or apolipoprotein mimetic peptide where the peptide has biological activity (e.g., lowers SAA, and/or increases paroxonase activity, and/or improves HDL inflammatory index, etc.) when the plant and/or the peptide is fed to a mammal.

主权项

1. A transgenic tomato plant comprising cells that express a peptide one or more domains of which comprise the amino acid sequence DWLKAFYDKFFEKFKEFF (SEQ ID NO: 17) wherein said peptide in a fruit of said plant is effective to decrease plasma levels of lysophosphatidic acid (LPA) in a mammal, and/or to decrease serum amyloid A (SAA) levels in said mammal, and/or to increase plasma paraoxonase activity in said mammal when said fruit is fed to said mammal as a lyophilized powder.