| 发明名称 | MELK regulation for the treatment of breast cancer | ||
| 摘要 | Methods for inhibiting growth or proliferation of breast cancer cells are provided. The methods include administering to a subject in need thereof in an amount that is effective to inhibit growth or proliferation of the breast cancer cells a MELK inhibitor, wherein the breast cancer cells are estrogen receptor (ER) negative. In some aspects, the methods include administering to a subject in need thereof in an amount that is effective to inhibit growth or proliferation of the breast cancer cells a MELK inhibitor, a FoxM1 inhibitor or a MELK inhibitor and a FoxM1 inhibitor, wherein the breast cancer cells are estrogen receptor (ER) negative. Methods of treatment for breast cancer and methods of identifying patients having cancer that are likely to benefit from treatment with a MELK inhibitor, a FoxM1 inhibitor or a MELK inhibitor and a FoxM1 inhibitor are also provided. | ||
| 申请公布号 | US9540619(B2) | 申请公布日期 | 2017.01.10 |
| 申请号 | US201414759889 | 申请日期 | 2014.01.08 |
| 申请人 | Novartis AG;Dana-Farber Cancer Institute, Inc. | 发明人 | Huang Xizhong;Zhao Jean J.;Min Junxia;Wang Yubao |
| 分类号 | C12N15/113;C12N9/12;A61K38/12;A61K31/7088;C12Q1/68 | 主分类号 | C12N15/113 |
| 代理机构 | Brinks Gilson & Lione | 代理人 | Brinks Gilson & Lione |
| 主权项 | 1. A method for inhibiting growth or proliferation of breast cancer cells comprising administering to a subject in need thereof in an amount that is effective to inhibit growth or proliferation of the breast cancer cells a MELK inhibitor, the MELK inhibitor comprising an inhibitory RNA having a MELK target nucleotide sequence selected from the group consisting of SEQ. ID. NO: 1, SEQ. ID. NO: 2, SEQ. ID. NO: 3 and SEQ. ID. NO: 4wherein the inhibitory RNA comprises a nucleotide sequence selected from the group consisting of SEQ. ID. NOS: 5-12;and wherein the breast cancer cells are estrogen receptor (ER) negative. | ||
| 地址 | Basel CH | ||