Immunostimulatory compositions and methods of manufacture

摘要

Immune-stimulatory compositions and methods of manufacture are described with an unexpectedly greater immunostimulatory effect on the immune system than the individual components alone. The compositions include a combination of arabinogalactan protein (AGP) compounds, particularly those derived from honey or with similar activity to honey derived AGP's along with apisimin proteins, peptides or functional fragments thereof, particularly those isolated from royal jelly or apisimin produced via recombinant methods.

主权项

1. An immunostimulatory composition comprising a therapeutically effective amount of:
a) honey derived AGP; and b) an isolated and/or purified apisimin protein comprising the sequence set forth in SEQ ID NO. 1 and/or one or more peptides with at least 95% homology thereto, wherein the concentration of honey derived AGP in the immunostimulatory composition is greater than approximately 1 μg/ml, the concentration of apisimin proteins or peptides in the immunostimulatory composition is greater than approximately 5 μg/ml, and wherein the combination of the AGP and apisimin protein and/or the one or more peptides stimulates an immune response.