发明名称 |
NON-HEMOLYTIC LLO FUSION PROTEINS AND USES THEREOF LLO |
摘要 |
A recombinant protein comprising a listeriolysin O (LLO) protein, wherein the LLO protein comprises a mutation, or deletion of 2-11 amino acid residues within the cholesterol-binding domain (CBD) of the LLO protein, and wherein the recombinant protein exhibits a greater than 100-fold reduction in hemolytic activity relative to wild-type LLO. The recombinant protein may further comprise a heterologous peptide, such as an antigenic peptide. |
申请公布号 |
HK1217341(A1) |
申请公布日期 |
2017.01.06 |
申请号 |
HK20160105309 |
申请日期 |
2016.05.10 |
申请人 |
The Trustees of The University of Pennsylvania |
发明人 |
PATERSON, Yvonne;MACIAG, Paulo |
分类号 |
C07K;A61K;C12N |
主分类号 |
C07K |
代理机构 |
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代理人 |
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主权项 |
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地址 |
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