METHOD OF DETECTING OR MONITORING AN IGG4-RELATED DISEASE BY DETECTING IGG4 KAPPA/LAMBDA HYBRID ANTIBODIES

摘要

Methods and assay kits for detecting or monitoring an Ig G4-related disease are provided, using antibodies or binding agents such as antibodies specific for immunoglobulins, the immunoglobulins comprising an Ig G class and a heavy chain subclass, further characterised by being bound to a kappa or lambda light chain class or multiple light chain classes. The total amount of such an immunoglobulin may be detected, or the ratio between immunoglobulins of the same Ig G class and heavy chain subclass but bound to either a kappa or lambda light chain class or both a kappa and a lambda light chain class may be detected.