ANTIBODIES TO RECEPTOR OF ADVANCED GLYCATION END PRODUCTS (RAGE) AND USES THEREOF

摘要

The present application relates to isolated proteins, particularly monoclonal antibodies, in particular CDR-grafted, humanized antibodies which bind to RAGE protein. Specifically, these antibodies have the ability to inhibit the binding of RAGE to its various ligands. The antibodies or portions thereof of described in the present application are useful for treating a disease or disorder characterized by or induced by pathophysiological ligands of RAGE, for example missfolded proteins like amyloid β and advanced glycation-end-products.

主权项

1. An isolated monoclonal antibody comprising an antigen binding domain, said antibody capable of binding an epitope of a human RAGE molecule, said antigen binding domain comprising at least one CDR comprising an amino acid sequence selected from:
a) the CDR-H3 group of amino acid sequences consisting of SEQ ID NO.: 4, 12 and 20; modified CDR amino acid sequences having a sequence identity of at least 50% to one of said sequences; and/or b) the CDR-L3 group of amino acid sequences consisting of SEQ ID NO.: 8, 16 and 24; and modified CDR amino acid sequences having a sequence identity of at least 50% to one of said sequences.