FUSION PROTEIN INHIBITING ANGIOGENESIS OR GROWTH AND USE THEREOF

摘要

Provided are a fusion protein inhibiting angiogenesis or vascular growth, coding sequence thereof, vector comprising the coding sequence, host cell, pharmaceutical composition and use of the fusion protein. The fusion protein of the present invention has high thermostability, and has a dramatic decline in the protein addredation formation rate in a fermentation process, and a significant increase in the purity and yield of the protein, and has better biological activity.

主权项

1. A fusion protein for the inhibition of angiogenesis or vascular growth, composed of a human VEGF receptor fragment and an Fc fragment of human immunoglobulin linked thereto, wherein the amino acid sequence of the VEGF receptor fragment is as shown in SEQ ID NO: 1, SEQ ID NO: 3 or SEQ ID NO: 5.