| 主权项 |
1. A compound of the following Formula (I-A):wherein
Ring A′ and Ring B′ are each independently a monocyclic or bicyclic aryl or heteroaryl; wherein one of Ring A′ and Ring B′ is a monocyclic aryl or heteroaryl and the other is a bicyclic heteroaryl; and at least one of Ring A′ and Ring B′ comprises at least one nitrogen ring member; each L1 and L2 is independently —C(R1′)(R2′)—, —O—, —N(Rk′)—, —S—, —S(O)— or —S(O)2—; each R1′ and R2′ are independently H, deuterium, halogen, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, 3- to 7-membered heterocycloalkyl, C6-10 aryl, or mono- or bicyclic heteroaryl, —ORa′, —OC(O)Ra′, —OC(O)NRa′Rb′, —OS(O)Ra′, —OS(O)2Ra′, —SRa′, —S(O)Ra′, —S(O)2Ra′, —S(O)NRa′Rb′, —S(O)2NRa′Rb′, —OS(O)NRa′Rb′, —OS(O)2NRa′Rb′, —NRa′Rb′, —NRa′C(O)Rb′, —NRa′C(O)ORb′, —NRa′C(O)NRa′Rb′, —NRa′S(O)Rb′, —NRa′S(O)2Rb′, —NRa′S(O)NRa′Rb′, —NRa′S(O)2NRa′Rb′, —C(O)Ra′, —C(O)ORa′, —C(O)NRa′Rb′, —PRa′Rb′, —P(O)Ra′Rb′, —P(O)2Ra′Rb′, —P(O)NRa′Rb′, —P(O)2NRa′Rb′, —P(O)ORa′, —P(O)2ORa′, —CN, or —NO2, or R1′ and R2′ taken together with the carbon or carbons to which they are attached form a C3-6cycloalkyl or a 4- to 6-membered heterocycloalkyl, wherein each hydrogen atom in C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, 3- to 7-membered heterocycloalkyl, C6-10 aryl, mono- or bicyclic heteroaryl, 4- to 6-membered heterocycloalkyl is independently optionally substituted by deuterium, halogen, C1-6alkyl, C1-6haloalkyl, —ORe′, —OC(O)Re′, —OC(O)NRe′Rf′, —OS(O)Re′, —OS(O)2Re′, —OS(O)NRe′Rf′, —OS(O)2NRe′Rf′, —SRe′, —S(O)Re′, —S(O)2Re′, —S(O)NRe′Rf′, —S(O)2NRe′Rf′, —NRe′Rf′, —NRe′C(O)Rf′, —NRe′C(O)ORf′, —NRe′C(O)NRe′Rf′, —NRe′S(O)Rf′, —NRe′S(O)2Rf′, —NRe′S(O)NRe′Rf′, —NRe′S(O)2NRe′Rf′, —C(O)Re′, —C(O)ORe′, —C(O)NRe′Rf′, —PRe′Rf′, —P(O)Re′Rf′, —P(O)2Re′Rf′, —P(O)NRe′Rf′, —P(O)2NRe′Rf′, —P(O)ORe′, —P(O)2ORe′, —CN, or —NO2; each Rk′ is independently H, deuterium, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, 3- to 7-membered heterocycloalkyl, C6-10 aryl, or mono- or bicyclic heteroaryl, wherein each hydrogen atom in C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, 3- to 7-membered heterocycloalkyl, C6-10 aryl, or mono- or bicyclic heteroaryl is independently optionally substituted by deuterium, halogen, C1-6alkyl, C1-6haloalkyl, —ORe′, —OC(O)Re′, —OC(O)NRe′Rf′, —OS(O)Re′, —OS(O)2Re′, —OS(O)NRe′Rf′, —OS(O)2NRe′Rf′, —SRe′, —S(O)Re′, —S(O)2Re′, —S(O)NRe′Rf′, —S(O)2NRe′Rf′, —NRe′Rf′, —NRe′C(O)Rf′, —NRe′C(O)ORf′, —NRe′C(O)NRe′Rf′, —NRe′S(O)Rf′, —NRe′S(O)2Rf′, —NRe′S(O)NRe′Rf′, —NRe′S(O)2NRe′Rf′, —C(O)Re′, —C(O)ORe′, —C(O)NRe′Rf′, —PRe′Rf′, —P(O)Re′Rf′, —P(O)2Re′Rf′, —P(O)NRe′Rf′, —P(O)2NRe′Rf′, —P(O)ORe′, —P(O)2ORe′, —CN, or —NO2; each R3′ and R4′ is independently deuterium, halogen, —ORc′, —OC(O)Rc′, —OC(O)NRc′Rd′, —OC(═N)NRc′Rd′, —OS(O)Rc′, —OS(O)2Rc′, —OS(O)NRc′Rd′, —OS(O)2NRc′Rd′, —SRc′, —S(O)Rc′, —S(O)2Rc′, —S(O)NRc′Rd′, —S(O)2NRc′Rd′, —NRc′Rd′, —NRc′C(O)Rd′, —NRc′C(O)ORd′, —NRc′C(O)NRc′Rd′, —NRc′C(═N)NRc′Rd′, —NRc′S(O)Rd′, —NRc′S(O)2Rd′, —NRc′S(O)NRc′Rd′, —NRc′S(O)2NRc′Rd′, —C(O)Rc′, —C(O)ORc′, —C(O)NRc′Rd′, —C(═N)NRc′Rd′, —PRc′Rd′, —P(O)Rc′Rd′, —P(O)2Rc′Rd′, —P(O)NRc′Rd′, —P(O)2NRc′Rd′, —P(O)ORc′, —P(O)2ORc′, —CN, —NO2, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, 3- to 7-membered heterocycloalkyl, C6-10 aryl, or mono- or bicyclic heteroaryl, or any two R3′ groups or any two R4′ groups taken together with the ring to which they are attached form a C5-8cycloalkyl or a 5- to 8-membered heterocycloalkyl, wherein each hydrogen atom in C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, 3- to 7-membered heterocycloalkyl, C6-10 aryl, mono- or bicyclic heteroaryl C5-8cycloalkyl or a 5- to 8-membered heterocycloalkyl is independently optionally substituted by deuterium, halogen, C1-6alkyl, C1-6haloalkyl, —ORe′, —OC(O)Re′, —OC(O)NRe′Rf′, —OS(O)Re′, —OS(O)2Re′, —OS(O)NRe′Rf′, —OS(O)2NRe′Rf′, —SRe′, —S(O)Re′, —S(O)2Re′, —S(O)NRe′Rf′, —S(O)2NRe′Rf′, —NRe′Rf′, —NRe′C(O)Rf′, —NRe′C(O)ORf′, —NRe′C(O)NRe′Rf′, —NRe′S(O)Rf′, —NRe′S(O)2Rf′, —NRe′S(O)NRe′Rf′, —NRe′S(O)2NRe′Rf′, —C(O)Re′, —C(O)ORe′, —C(O)NRe′Rf′, —PRe′Rf′, —P(O)Re′Rf′, —P(O)2Re′Rf′, —P(O)NRe′Rf′, —P(O)2NRe′Rf′, —P(O)ORe′, —P(O)2ORe′, —CN, or —NO2; R7′ is H, deuterium, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, 3- to 7-membered heterocycloalkyl, C6-10 aryl, or mono- or bicyclic heteroaryl, wherein each hydrogen atom in C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, 3- to 7-membered heterocycloalkyl, C6-10 aryl, or mono- or bicyclic heteroaryl is independently optionally substituted by deuterium, halogen, —ORi′, —OC(O)Ri′, —OC(O)NRi′Rj′, —OS(O)Ri′, —OS(O)2Ri′, —OS(O)NRi′Rj′, —OS(O)2NRi′Rj′, —SRi′, —S(O)Ri′, —S(O)2Ri′, —S(O)NRi′Rj′, —S(O)2NRi′Rj′, —NRi′Rj′, —NRi′C(O)Rj′, —NRi′C(O)ORj′, —NRi′C(O)NRi′Rj′, —NRi′S(O)Rj′, —NRi′S(O)2Rj′, —NRi′S(O)NRi′Rj′, —NRi′S(O)2NRi′Rj′, —C(O)Ri′, —C(O)ORi′, —C(O)NRi′Rj′, —PRi′Rj′, —P(O)Ri′Rj′, —P(O)2Ri′Rj′, —P(O)NRi′Rj′, —P(O)2NRi′Rj′, —P(O)ORi′, —P(O)2ORi′, —CN, or —NO2; each Ra′, Rb′, Rc′, Rd′, Re′, Rf′, Ri′ and Rj′ is independently selected from the group consisting of H, deuterium, C1-6alkyl, C2-6alkenyl, C2-6alkynyl, C3-6cycloalkyl, 3- to 7-membered heterocycloalkyl, C6-10 aryl, and heteroaryl; m′ is 2, 3, 4, or 5; n′ is 2, 3, or 4; p′ is 0, 1, 2, 3, or 4; and q′ is 0, 1, 2, 3, or 4;or a pharmaceutically acceptable salt thereof. |
