MODIFIED EXTRACELLULAR MATRIX FOR ENHANCED STEM CELL HOMING AND ENGRAFTMENT

摘要

Disclosed are compositions comprising a decellularized ECM (extracellular matrix) and at least one signaling marker, wherein the signaling marker is coupled to the decellularized ECM. The compositions may further comprise demineralized bone matrix. In some embodiments, the decellularized ECM and the at least one signaling molecule are biotinylated. In some aspects, the at least one signaling marker is coupled to the decellularized ECM by streptavidin. Also disclosed are the methods of producing the compositions and the methods of using the compositions.