The factor H binding activity of meningococcal fHBP can be uncoupled from its bactericidal sensitivity. NMR studies have identified various amino acid residues involved in the fHBP/fH interaction and one or more of these residues is modified in a fHBP to reduce or eliminate its ability 5 to bind to fH.
申请公布号
AU2016273825(A1)
申请公布日期
2017.01.05
申请号
AU20160273825
申请日期
2016.12.12
申请人
Novartis AG
发明人
Banci, Lucia;Cantini, Francesca;Dragonetti, Sara;Gentile, Maria Antonietta;Veggi, Daniele;Scarselli, Maria;Pizza, Mariagrazia
